Meadville is a town in and the county seat of Franklin County, Mississippi, United States, in the southwest part of the state. The population was 449 at the 2010 census, down from 519 at the 2000 census. It is situated north of the Homochitto River, which runs from the northeast to the southwest through the county on its way to its outlet at the Mississippi River.
Meadville is located in the center of Franklin County at 31°28′23″N 90°53′27″W (31.472998, -90.890856). U.S. Routes 98 and 84 bypass the town to the south. US 84 leads east 32 miles (51 km) to Brookhaven, and US 98 leads southeast 36 miles (58 km) to McComb. Together the highways lead west 32 miles (51 km) to Natchez. According to the United States Census Bureau, Meadville has a total area of 1.1 square miles (2.9 km²), all land.
As of the census of 2000, there were 519 people, 187 households, and 126 families residing in the town. The population density was 469.2 people per square mile (180.5/km²). There were 220 housing units at an average density of 198.9 per square mile (76.5/km²). The racial makeup of the town was 82.85% White, 15.41% African American, 0.77% Asian, and 0.96% from two or more races. Hispanic or Latino of any race were 0.58% of the population.
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